Doctors predict that in a few years, mankind can start struggle against infectious diseases all over again. And all because two most valuable inventions of mankind in pharmacology – antibiotics and vaccines – in our enlightened XXI century were caught in a web of myths and prejudices.
Antibiotics are substances mainly of natural origin, which are produced as a rule by fungi. They kill or inhibit bacteria growth that cause pneumonia, sepsis, meningitis and are absolutely useless against viruses – causative agents of ARVI, influenza, hepatitis A, chicken pox, measles and other diseases.
Appearance of the first antibiotic – benzylpenicillin, or simply penicillin – in 1928 was an accidental discovery of Alexander Fleming, who discovered that staphylococci culture was dying under mold fungi bacteria action. However, mass production of antibiotics began only 17 years later – in 1945. Emergence of these antibiotics has ceased to be «a rule of thumb», but was determined by bacterial landscape, that is, predominance of particular bacteria type at the moment. Now antibiotics include about 30 classes of drugs and about 150 – 180 registered original drugs. However, according to Canadian Health&Care Mall pharmacologists, production of new antibiotics came to deadlock: during the last 10 years there were created only 2 – 3 new drugs.
Why don’t Antibiotics Work?
When hospitals began to use penicillin, mortality rate in maternity hospital from infections caused by staphylococci (most common at that time kind of bacteria), it decreased by hundreds of times, which allowed to save lives of mothers and children. However, after 50 years 99% of staphylococcus bacteria are no longer susceptible to penicillin – they have developed resistance to the drug. After a crazy effect of the first antibiotic, doctors began to prescribe them for infections, which we believe now insignificant and do not require such drugs intake. As a result, during less than a hundred years, antibiotics managed to cover all the way from its dawn to sunset.
The number one problem with antibiotics is now considered development of drug resistance and emergence of 5 – 7 bacteria, which are difficult to treat with existing drugs, such as Pseudomonas aeruginosa, Staphylococcus aureus, or pneumococcus.
Development of bacterial resistance to antibiotics was triggered by irrational use of medicines – both by doctors and patients.
For example, a mother with coughing child with high body temperature came to physician. The doctor by the eye can not detect bacterial infection or virus, but to be on the safe side, not to miss dangerous condition, prescribes antibiotics.
Preventive effect as such doesn’t present in antibiotics, but there are clear indications to assign antibiotics, for example, at patients with immunodeficiency. But it is easier for the doctor to prescribe antibiotics to protect themselves and patient.
What happens next? Pack of purchased once broad-spectrum antibiotic is present at home, and when a child falls ill again, parents give him the same pills – according to their logic, since the child has the same symptoms, then it should be treated the same way. Introducing antibiotic in the body for a long time (especially at low dosage) leads to development of microbial resistance to the drug.
Antibiotics Side Effects
All antibiotics, according to Canadian Health&Care Mall, one way or another, have side effects that are not always known to doctors, because in some cases they are unobtrusive and do not cause significant harm to patient’s health. But some people manage not to pay attention even to «screaming» side effects.
For example, gentamicin antibiotic (related to II generation of aminoglycoside group) has two serious side effects – oto- and nephrotoxicity. As well as entire group of drugs (it is not developed now): Amikacin, Bramitob, Isofra, Kanamycin, Cyrinus, Neomycin, Streptomycin, Toby, Tobramycin and others. Gentamicin can accumulate in middle ear and kidney tissues. On the one hand, it can effectively treat diseases of these bodies, but on the other, they cause serious complications – irreversible deafness and reversible kidney damage.
However, doctors, according to Canadian Health&Care Mall, may not notice this side effects, since deafness may not be complete, but partial. Easy audiometry could help to notice hearing loss, but who will carry it out at pyelonephritis treatment? Therefore, if possible it is better to choose other antibiotics group – not aminoglycosides, but for example, cephalosporins ( Azaran, Vicef, Ceftobiprole, Kefotex, Klaforan, Lyzolin, Maxipime, Nacef, Orzid, Oframax, Proxime, Rocephin, Suprax, Torocef, Fortum, Cefazolin, Ceftriaxone and others).
Vancomycin has a similar ototoxicity effect (Vancomycin, Vancocin, Edicin) – antibiotic of tricyclic glycopeptide group.
Antibiotics of tetracycline group ( Vibramicin, Doxycycline, Xedocine, Unidox Solutab, Tetracycline) do not cause deafness, unlike aminoglycoside, but 100% of men observe spermatogenesis (sperm production) violation which may recover or maybe not. As explained by Canadian Health and Care Mall pharmacologists, tetracycline antibiotics are among the most toxic: they cause violation of bone and teeth formation. Even at local application in the form of ointments, particularly at children, can cause such disorders.
Antibiotics toxic effects are dosage-dependent. This means that the longer and the more you take the medicine, the more possible side effects development is. Therefore, the most important rule when taking antibiotics – strict adherence to intake frequency and therapy duration prescribed by doctor. The least toxic antibiotics are penicillins (Ampicillin, Ecobol and others), and macrolide antibiotics (Azitrox, Wilprafen, Klabax, Claricin, Klacid, Rulid, Sumamed, Sumamox, Fromilid, Erythromycin and others). But this does not mean that they are absolutely safe.
For example, if a person has allergy to antibiotics, most likely, it appears in case of introduction of penicillins and cephalosporins. Thus, for severe allergic reaction – anaphylactic shock, which in 70% of cases leads to death, even a small contact with allergen is enough.
Risk is also in the fact that patient can already suffer from allergy to antibiotics, but he does not know about it – we eat meat, «pumped» with antibiotics, and on this background, additional intake of even small doses of penicillin may cause severe allergic reaction, but can also cause death.
What don’t Patients Know?
Most patients taking antibiotics, one way or another, heard about that at this time it is better to abstain from alcohol. The fact is that co-administration of antibiotics and alcohol can not only reduce these drugs effectiveness, but also cause severe side effects, including death.
Ethanol affects liver enzyme activity and its ability to metabolize antibiotics. As a result, when alcohol is used in combination with erythromycin its concentration is simply decreased, but chloramphenicol preparations containing ketoconazole (Nizoral and other antifungal antibiotics), furasolidone chemically interact with alcohol, which leads to serious side effects, even to convulsions, severe dyspnea and death. Drinking alcohol with these antibiotics is strictly contraindicated.
Antibacterials for Children are not Profitable
Another problem with antibiotics remains absence of pharmaceutical forms for children.
Medications is a business. And since main antibiotics consumers are still adults, pharmaceutical companies are not engaged in production of pharmaceutical forms for children because it is unprofitable.
The result is that «adult» pill is divided in half and given to the child. However, in this case, drug effectiveness may simply come to naught.
Pills are protected by special coat that allows them to not be dissolved by hydrochloric acid action in stomach. There are medicines that are particularly sensitive to acid, and if we crush a pill, we break its structure and the drug is simply dissolved and ceases to act. This happens, for example, with erythromycin drugs.
Antibiotics + Probiotic = Money Down the Drain
One of the most unpleasant symptoms of antibiotics side effects, even at proper reception – diarrhea. Advertising and doctors tell us that from the first day of taking medication you need to take drugs that restore intestinal microflora. However, it often turns out that they just make us buy useless medicines.
Diarrhea, which appeared after taking antibiotics, is a side effect of drug action. Our intestines and entire body is inhabited by bacteria, most of them – anaerobic microorganisms. Antibiotics, destroying harmful bacteria, also kill useful, causing short-term diarrhea.
By action spectrum antibiotics may be active against anaerobic bacteria, but may not be. For example, one of toxic antibiotics groups – aminoglycosides – does not cause diarrhea, because it is not active against anaerobic microorganisms that inhabit intestines. But non-toxic macrolide antibiotics can act on bifidus bacteria and cause diarrhea, as well as modern so-called «protected» penicillins and some cephalosporins.
Intestinal microflora killer number one is metronidazole (Trichopol) and clindamycin, according to Canadian HealthCare Mall specialists.
Healthy body is able to independently restore microflora without external intervention. However, it is easier to think that we need to saved by pills. Probiotics, which are recommended to take with antibiotics, are also bacteria, they can also be exposed to antibiotics. Therefore, , doctor should select probiotic drug strictly in accordance with antibiotic activity.
For example, popular Linex drug includes gram-positive organisms, which are easily «killed» by macrolide, tetracycline and penicillin antibiotics. But Bifidumbacterinum includes gram-negative bacilli, which is resistant to most antibiotics, except for some cephalosporins and fluoroquinolones – very popular and commonly prescribed antibiotics.